Friday, August 14, 2009

Shiitake Extract Used in Asia as Cancer Medication

By Dr. Markho Rafael

In Europe and America, "mushrooms" in a recipe usually refers to button mushrooms (Agaricus bisporus), which were first cultivated in France in the 1600's. In Far East Asia, the equivalent is Shiitake, which has long been the cultivated "food mushroom" of choice. Only in the past few decades has Shiitake become a household name in western cuisine.

Also known as Chinese Mushroom or Black Mushroom, wild Shiitake is strictly an Asian species. It derives its name from one of its hosts, the Shii Tree, but can also be found growing on Asian oaks and beeches. Cultivating Shiitake is a tradition that stretches back approximately 1000 years in China.

Although most westerners are now familiar with Shiitake as a food mushroom, few know that it's also the most researched medicinal mushroom in Asia. As with other medicinal mushrooms, the research has largely focused on applications against cancer, [94] but also on its anti-viral properties. [93]

The preferred part of Shiitake to use medicinally is the mycelium (the "roots") because they contain compounds that either don't exist in the fruit body ("mushroom"), or are much more concentrated in the mycelium.

The most researched Shiitake extract is known as LEM, short for Lentinula Edodes Mycelia. (Shiitake's Latin name is Lentinula edodes.) Research has found LEM to enhance the immune system, [95, 96, 97] especially against bacterial infection. [98, 99] It's also been reported to be anti-tumoral. [100] A 2005 study published findings that it killed melanoma cells while sparing non-diseased tissue. [101]

Lentinan is the name of another much researched compound isolated from Shiitake, named after the Latin genus name Lentinula. Lentinan is a polysaccharide that has been found to stimulate the human immune system to combat cancer. [102, 103, 104, 105, 106, 107, 108, 109, 110] It is currently used in Asia as an intravenous cancer drug.

Arabinoxylanes, compounds resulting from Shiitake-on-rice fermentation, have also demonstrated significant anti-viral activity. [111, 112, 113]

Specifically herpes simplex virus type 1 [114] and more importantly HIV have responded to Shiitake extracts in several studies. [115, 116, 117] However, the previously mentioned Lentinan polysaccharide, by itself, has no significant effect on the replication of HIV. [25]

Other studies worth a brief mention have reported positive findings in the use of Shiitake extract to prevent septic shock, [120] and to treat Candida [118] and chronic fatigue syndrome. [119]

In his book Mycelium Running, medicinal mushroom expert Paul Stamets also lists the following areas where research has shown Shiitake extract to have a beneficial effect: Blood Pressure; Blood Sugar; Cholesterol; Kidney Tonic; Liver Tonic; Sexual Potentiator; Stress; Breast Cancer; Liver Cancer; Prostate Cancer. [134]

Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Never use any medicinal mushroom or herb without prior approval by medical doctor.

Credit to Paul Stamets for research and source material.

About the Author: