Although originating in the wild from fields northwest of Sao Paolo, Brazil, the cultivation of Agaricus blazei as a medicinal mushroom was originated in 1993 by Japanese mycologists.
As with most medicinal mushrooms, the primary focus of research on Agaricus extract has been on its anti-tumoral properties. Results are promising, particularly in regard to uterocervical cancers. [25]
One study reported that Agaricus extract contained a higher level of beta glucans than any other medicinal mushroom. So while not included in this article, it may be worthwhile to also look into beta glucan related research. [25]
Research on Agaricus extract against cancer cell cultures (in vitro) have yielded primarily negative results, but testing on live individuals (in vivo) have shown some positive results. What this tells us is that Agaricus blazei's effect on cancer is by stimulating the immune system rather than killing off cancer cells directly. [135, 136, 137, 138, 139, 140]
In 2002, a Japanese study presented results indicating that Agaricus extract stimulates the immune system to perform a two-stage attack against cancer cells. In stage one, eight hours after administering Agaricus extract, the macrophages (white blood cells) excreted "alpha tumor necrosis factor," a well-known cancer killing compound. In stage two, which happened an additional four hours later, another compound was excreted by the same macrophages to finish off cancer cells weakened by the initial attack. [141]
Another specific cancer related effect of Agaricus extract is that it inhibits the enzyme aromatase, which is associated with the development of breast cancer. [142]
Both water and alcohol extracts of Agaricus blazei contain potentially important therapeutic compounds. [143] The mycelium ("roots") in particular appear to contain high concentrations. [25]
In addition to showing promise as cancer medicine, Agaricus extract also demonstrates antibacterial properties. In one study, it was particularly effective against salmonella. [144]
Finally a few words of caution: One test in 2003 showed that Agaricus blazei grown in China contained a significantly larger amount of cadmium than Agaricus grown in the United States. [145]
It should also be pointed out that while research shows great promise for the use of Agaricus extract in the battle against cancer, ironically, Agaricus blazei mushrooms also contain cancer causing compounds known as agaritines. (Agaritines are also found in Button Mushrooms, Portobellos and Crimini Mushrooms.)
In 2003, Stijve et al. published a comparative study of agaritines between Agaricus blazei from different sources. The extract of Paul Stamets' Agaricus blazei grown in Washington State contained eighty-fold less of the carcinogenic agaritines than the samples from China, and twenty times less than samples from California. [145]
"Years ago, Paul Stamets ... developed methods that precluded agaritines, and Stijve et al. (2003) published a comparison of commercial products from the US, China, and Japan. All but [Paul Stamets] products contained significant amounts of agaritine." [145]
In his book Mycelium Running, medicinal mushroom expert Paul Stamets also lists the following areas where research has shown Agaricus extract to have a beneficial effect: Viruses; Blood Sugar; Cholesterol; Colorectal Cancer; Sarcoma. [134]
Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Always consult a licensed medical practitioner before using any herb (or mushroom) for medicinal purposes.
As with most medicinal mushrooms, the primary focus of research on Agaricus extract has been on its anti-tumoral properties. Results are promising, particularly in regard to uterocervical cancers. [25]
One study reported that Agaricus extract contained a higher level of beta glucans than any other medicinal mushroom. So while not included in this article, it may be worthwhile to also look into beta glucan related research. [25]
Research on Agaricus extract against cancer cell cultures (in vitro) have yielded primarily negative results, but testing on live individuals (in vivo) have shown some positive results. What this tells us is that Agaricus blazei's effect on cancer is by stimulating the immune system rather than killing off cancer cells directly. [135, 136, 137, 138, 139, 140]
In 2002, a Japanese study presented results indicating that Agaricus extract stimulates the immune system to perform a two-stage attack against cancer cells. In stage one, eight hours after administering Agaricus extract, the macrophages (white blood cells) excreted "alpha tumor necrosis factor," a well-known cancer killing compound. In stage two, which happened an additional four hours later, another compound was excreted by the same macrophages to finish off cancer cells weakened by the initial attack. [141]
Another specific cancer related effect of Agaricus extract is that it inhibits the enzyme aromatase, which is associated with the development of breast cancer. [142]
Both water and alcohol extracts of Agaricus blazei contain potentially important therapeutic compounds. [143] The mycelium ("roots") in particular appear to contain high concentrations. [25]
In addition to showing promise as cancer medicine, Agaricus extract also demonstrates antibacterial properties. In one study, it was particularly effective against salmonella. [144]
Finally a few words of caution: One test in 2003 showed that Agaricus blazei grown in China contained a significantly larger amount of cadmium than Agaricus grown in the United States. [145]
It should also be pointed out that while research shows great promise for the use of Agaricus extract in the battle against cancer, ironically, Agaricus blazei mushrooms also contain cancer causing compounds known as agaritines. (Agaritines are also found in Button Mushrooms, Portobellos and Crimini Mushrooms.)
In 2003, Stijve et al. published a comparative study of agaritines between Agaricus blazei from different sources. The extract of Paul Stamets' Agaricus blazei grown in Washington State contained eighty-fold less of the carcinogenic agaritines than the samples from China, and twenty times less than samples from California. [145]
"Years ago, Paul Stamets ... developed methods that precluded agaritines, and Stijve et al. (2003) published a comparison of commercial products from the US, China, and Japan. All but [Paul Stamets] products contained significant amounts of agaritine." [145]
In his book Mycelium Running, medicinal mushroom expert Paul Stamets also lists the following areas where research has shown Agaricus extract to have a beneficial effect: Viruses; Blood Sugar; Cholesterol; Colorectal Cancer; Sarcoma. [134]
Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Always consult a licensed medical practitioner before using any herb (or mushroom) for medicinal purposes.
About the Author:
Dr. Rafael has worked with natural health since finishing Chiropractic College in the mid-90's. He now focuses on medicinal fungi, including Extract of Agaricus, in partnership with Cordyceps Reishi Extracts, LLC. For the scientific references to this article, go to the Extract of Agaricus blazei page and click on any number indicating a reference.
